Non Medicated Tulle Dressing

DESCRIPTION
Atrauman is a ready to use Tulle, impregnated with hydrophobic neutral ointment base (Yellow soft paraffin)

FEATURES & BENEFITS
• Paraffin maintains a moist environment & prevents adherence to surface
• Allows easy drainage of wound exudates
• Changing of dressing is painless due to non-adhesion to wound
• Has high absorbency that keeps even heavy exuding wounds clean
• It is terminally sterilized by gamma irradiation

INDICATIONS
• Minor burns & scalds
• Lacerations, Abrasions and other skin loss wounds
• Donor and Recipient graft sites
• Leg ulcers


CONTRA INDICATIONS
Although there are no absolute contra-indications to the use of Atrauman, if the dressing is placed upon a heavily exuding wound, its semi-occlusive nature may cause tissue maceration by preventing the free movement of exudate away from the surface of the wound. This is less likely to occur if a dressing bearing the lower loading of paraffin base is used.


APPLICATION PROCEDURE
Atrauman is applied directly to the surface of the wound and covered with an absorbent pad held in place with tape or a bandage, as appropriate. Frequency of Change: The frequency of dressing changes will depend entirely upon the nature of the wound. If Atrauman is left in position for prolonged periods of time, it can become adherent and cause tissue damage upon removal.

PRESENTATION
Atrauman 10 cm x 10 cm (20 dressings in an Aluminium container) Atrauman 10 cm x 10 cm (2 dressings in a pouch pack)

Chlorhexidine Medicated Tulle Dressing

DESCRIPTION
Atrauman C is a ready to use Tulle, impregnated with Chlorhexidine

FEATURES & BENEFITS
• Chlorhexidine is active against a wide range of bacteria thus controls bacterial overgrowth.
• No cross-resistance has been demonstrated
• Change of dressing is painless due to the non-adherent property
• Terminally sterilized by gamma irradiation

INDICATIONS
• Recommended for prophylaxis on vulnerable wounds to reduce the risk of infection ? In already infected wounds can be used in conjunction with other topical & systemic antibacterial agents
• Postoperative dressings particularly after plastic surgery, skin transplants

CONTRAINDICATIONS
Atrauman C should not be used on more than 10% of the body area. Dermatitis, contact sensitivity or photosensitivity may rarely occur. Anaphylactic reaction to Chlorhexidine has been reported, but is rare. Avoid contact with eyes, the middle ear, meninges and brain. Atrauman C is incompatible with soaps, other anionic materials, as well as potassium iodide. The use of Atrauman C with oxidizing wound cleaning agents should be avoided.

APPLICATION PROCEDURE
Atrauman C is applied directly to the surface of the wound and covered with an absorbent pad held in place with tape or a bandage, as appropriate Frequency of Change: Atrauman C may be left in place when the absorbent secondary dressing is changed. The frequency of changing will depend on the clinical circumstances and this can vary from more than once per day to twice per week. If the dressing adheres, soak it gently with sterile saline solution.

PRESENTATION
Atrauman C 10 cm x 10 cm (20 dressings in an Aluminium container) Atrauman C 10 cm x 10 cm (2 dressings in a pouch pack)

COMPOSITION
Clostebol Acetate …….0.5% w/w
Neomycin Sulphate …….0.5% w/w

DESCRIPTION

Clostagen is a combination of Clostebol Acetate, a potent tissue regenerator and Neomycin Sulphate, an antibiotic of first choice for topical application. HIGHLIGHTS • The tissue regenerator with an antibiotic
• Accelerates granulation tissue formation
• Creates conditions conducive for healing

CLINICAL PHARMACOLOGY

Clostabol Acetate is 4 chlorotestosterone which is a testosterone derivative inducing protein synthesis. Hence, Clostebol Acetate is an anabolic steroid bringing about protein synthesis. Clostebol Acetate stimulates repair of ulcers, lesions, skin dystrophies as a result of increased protein synthesis. Neomycin controls the infection which often interferes with the healing process. Thus, Clostagen, when applied topically is an effective treatment for faster healing of lesions involving both skin and mucosa. It exerts trophic and cicatrizing effects and reduces healing time when applied topically

Mechanism of action
Clostagen encourages in the injured tissues – the retention and fixation of nitrogen of mineral salts and of other substances necessary for protein synthesis.
This stimulates:
Transformation of fibrocytes into fibroblasts with, subsequent formation of collagen fibres.
It also accelerates the synthesis of acid mucopolysaccharides and their further transformation into neutral mucopolysaccharides which constitute the cementing substances.
Epithelial component of the cicatrisation process is rapidly influenced with a remarkable acceleration of the process of Re-epithelialization.

Association with neomycin:
Neomycin Sulphate is necessary to control the infection. Infection delays the restoration of tissue. Hence the presence of Neomycin Sulphate, in Clostagen.

INDICATIONS
• Episiotomy wounds
• Nipple Fissures
• Anal Fissures
• Circumcisions

CONTRAINDICATIONS
Clostagen is contraindicated in cases of known hypersensitivity to its components.

PRECAUTIONS
The continuous use of Clostagen should be avoided, especially in very early infancy. As the use of Neomycin involves a potential risk of ototoxicity and nepharotoxicity, it is not advisable to use Clostagen, on extensively affected areas which may increase absorption of the antibiotic.

ADVERSE REACTIONS
The use of topical products, especially if prolonged, can give rise to patient sensitization. Continued application for several weeks on large areas of damaged tissue my possibility, cause systemic effects such as hypertrichosis due to absorption of Clostebol.

APPLICATION PROCEDURE
? 1-2 applications daily. Spread a thin layer of cream on the affected area and cover with sterile gauze, if required.
? Baby should be fed only after 30mins.
? Before feeding the baby wash the nipples thoroughly with soap and water.

PRESENTATION
Clostagen cream is available in a 10 gm tube

Changes marked in OXOFERIN
FOR APPLICATION PROCEDURE BOOKLET REFER PPT ATTACHED FOR CURRENT PRICE OF MUCODYNE AND MUCOBRON CONTACT RESPECTIVE PRODUCT MANAGER AND ADD IN THE FILE NAMED PATIENT INFO

Post-op Dressing

DESCRIPTION

Cosmopor E is a self-adhesive wound dressing, which differs from traditional wound dressings with its novel combination of materials

FEATURES & BENEFITS
Wound contact layer which is water repellent, allows exudates to pass into the absorbent pad below, whilst it remaining absolutely dry. This prevents the dressing from sticking to the wound. Absorbent pad made up of 100% pure cotton wool, adapts well to the body contours and has excellent absorbency with cushioning properties. It allows absorption of blood and serous material in immediate post-operative stage. Cotton pad does not allow mild exudate to escape out Non woven support is permeable to both air and water vapour thus Cosmopor E does not interfere with the skin's natural functions, has rounded edges which prevents the dressing from becoming detached even when applied on difficult-to-retain areas. Wide, adhesive border ensures good closure. This together with the water repellent, non-woven covering layer gives reliable protection against the contamination of wound. Cosmopor E is coated with a hypoallergenic polyacrylate adhesive that is well tolerated by the skin.

INDICATIONS

• Post operative wound management
• Sterile dressing for minor injuries

APPLICATION PROCEDURE

Select the appropriate size as per the wound. Remove the paper backing and directly apply over the wound. No additional fixation required.

PRESENTATION
7.2 x 5 cm for Laproscopic surgery
15 x 8 cm for Gastrointestinal surgery
25 x 10 cm for Orthopedic surgery
35 x 10 cm for C-section, big size cuts

COMPOSITION
Silver suphadiazine USP ……… …………1.0%
Chlorhexidine Gluconate …………….. 0.2%
as Chlorhexidine gluconate solution I.P. 1.0

DESCRIPTION
C.S.S. - Chlorhexidine Gluconate 0.2% and Silver Sulphadiazine 1.0% act as broad spectrum anti-microbials for the prophylaxis of burn wound infection.

CLINICAL PHARMACOLOGY
Silver Sulphadiazine is active against gram –ve organisms
Chlorhexidine is active against both gram +ve & -ve organisms
Chlorhexidine is highly active against Staphylococcus aureus against which Silver Sulphadiazine is less effective.

HIGHLIGHTS
Clinically proven higher efficacy Helps reduce emergence of resistance

INDICATIONS
Burns (First, second and third degree burns) Open wounds prone to infection

CONTRAINDICATIONS
Known Hypersensitivity to its ingredients Premature neonates or neonates younger than 2 months of age

PRECAUTIONS
Impaired hepatic or renal function Pregnancy & lactation Discontinuance of the drug should be considered if an allergic reaction develops during therapy Avoid contact with eyes and ears

DOSAGE AND ADMINISTRATION
Following cleansing & debridement of the wound, the cream is applied with a sterile hand upto a thickness of 1 to 3 mm. Once daily application adequate, although some patients require a twice daily application.

PRESENTATION
CSS cream is available in
10 gm tubes
250 gm jars
500 gm jars

COMPOSITION
Each 1g vial of Eldcef contains:
Ceftizoxime sodium : 1 g (dry powder)
Each 250 mg vial of Eldcef contains:
Ceftizoxime sodium: 250 mg (dry powder)

DESCRIPTION
Ceftizoxime is a sterile, semisynthetic, broad-spectrum, betalactamase resistant cephalosporin antibiotic for parenteral (IV, IM) administration.

HIGHLIGHTS
(USPs) Broad spectrum third generation cephalosporin Lower MICs than Cefotaxime for several gram negative organisms Stable to even extended spectrum beta-lactamases Low resistance levels Highest anti-anaerobic action amongst cephalosporins Safer than ceftriaxone

CLINICAL PHARMACOLOGY
Eldcef contains Ceftizoxime, 3rd generation cephalosporin with a broad spectrum of activity against gram+ve, aerobic as well as anaerobic bacteria. Ceftizoxime acts by inhibiting the bacterial cell wall synthesis, thus exhibiting a bactericidal effect.
A serum half-life of approximately 1.7 hours was observed after IV or IM administration.
Ceftizoxime is 30% protein bound.
Ceftizoxime is not metabolized, and is excreted virtually unchanged by the kidneys in 24 hours. This provides a high urinary concentration.
Ceftizoxime achieves therapeutic levels in various body fluids, e.g., cerebrospinal fluid (in patients with inflamed meninges), bile, surgical wound fluid, pleural fluid, aqueous humor, ascitic fluid, peritoneal fluid, prostatic fluid and saliva, and in the following body tissues: heart, gallbladder, bone, biliary, peritoneal, prostatic, and uterine. In clinical experience to date, no disulfiram-like reactions have been reported with Ceftizoxime.
MICROBIOLOGY
Ceftizoxime is highly resistant to a broad spectrum of beta-lactamases (penicillinase and cephalosporinase), including Richmond types I, II, III, TEM, and IV, produced by both aerobic and anaerobic gram-positive and gram-negative organisms. Ceftizoxime is active against a wide range of gram-positive and gram-negative organisms.

INDICATIONS AND USAGE
• Lower Respiratory Tract Infections
• Urinary Tract Infections
• Meningitis
• Intra-Abdominal Infections
• Septicemia
• Skin and Skin Structure Infections
• Bone and Joint Infections
• Gonorrhoea
• Pelvic Inflammatory Disease

CONTRAINDICATIONS
Eldcef is contraindicated in patients who have known allergy to the drug.

PRECAUTIONS
Eldcef should be prescribed with caution in individuals with a history of gastrointestinal disease, particularly colitis. Eldcef should be administered with caution in patients suffering from renal impairment and hypersensitivity to penicillin. Renal and hematological status should be monitored, especially during prolonged and high dose therapy.

DRUG INTERACTIONS
Although the occurrence has not been reported with ceftizoxime, nephrotoxicity has been reported following concomitant administration of other cephalosporins and aminoglycosides. Pregnancy Pregnancy Category B: Ceftizoxime should be used during pregnancy only if clearly needed. Nursing Mothers Ceftizoxime is excreted in human milk in low concentrations. Caution should be exercised when ceftizoxime is administered to a nursing woman. Pediatric Use Safety and efficacy in pediatric patients from birth to six months of age have not been established. However there are studies available which report that Ceftizoxime is very safe even in premature babies and infants and do not cause any sever side effects.

ADVERSE REACTIONS
Eldcef is generally well tolerated. The most frequent adverse reactions are:
• Rash, pruritus, fever
• Transient elevation in AST, ALT & alkaline phosphatase, Transient eosinophilia, thrombocytosis
• Local burning, cellulitis, phlebitis with IV administration, pain, induration, tenderness, paresthesia
• Rare : Numbness, anaphylaxis, anemia, vaginitis etc.

DOSAGE AND ADMINISTRATION

Crepe Bandage

DESCRIPTION
Hospicrepe is crepe bandage made of superior quality combed yarn to give it excellent stretch and regain properties

FEATURES & BENEFITS
• Made of superior quality combed yarn
• Excellent stretch and regain properties for all kinds of compression & support
• Having being constructed from cotton & viscose it is dermophillic, permeable to air & does not slip
• Bandage is resistant to wound secretions, ointments & sweat
• A conspicuous indicator line for correct overlap, uniform tension better contrast & visibility
• Bandage can be washed and boiled or, if required sterilized

INDICATIONS
• For support & relief subsequent to removal of plaster casts.
• Supportive bandage for sprains, strains & injuries.
• As a securing bandage for grafts & pressure dressing for burns.

PRESENTATION
Hospicrepe 10 cm x 4 m Hospicrepe 15 cm x 4 m

Elastic Adhesive Bandage

DESCRIPTION
Hospiplast is elastic adhesive bandage made of lanolin

FEATURES & BENEFITS
• Hospiplast enjoys the very same features & benefits of Hospicrepe as it is made from the same crepe material.
• The presence of Lanolin makes it skin friendly & ensures an easy release
• A special technique of coating makes the bandage adhesive porous, due to which it is permeable to air and moisture making it skin tolerant. Coating is uniformly applied & not spread to the edge of the bandage (Prevents rucking.)
• Bandage is x-ray permeable. Line indicator (Accurate tension and correct overlap)Adheres reliably, can be moulded as per body contours (Remains in place till full use)

INDICATIONS
Suitable as a Postoperative dressing and for other indications (strapping).

PRESENTATION
Hospiplast 8 cm x 4/6 m Hospiplast 15 cm x 4 m

COMPOSITION
Hydrocolloid Dressing containing hydrocolloid matrix of pectin, gelatin and carboxymethylcellulose (CMC)

DESCRIPTION
Hydrocoll is a self-adherent absorbent hydrocolloid dressing. Hydrocolloid contains hydro active colloids. ‘Colloid’ means a substance that is integrated in a matrix when dispersed into its smallest constituents. Hydrocolloids are absorbent and can retain moisture. Polyurethane layer that is a semi-permeable film covers the hydrocolloids and functions as a bacteria and waterproof covering layer.

HIGHLIGHTS
• Allows natural healing by forming a moist gel and thereby maintaining a moist environment
• Stimulates cell proliferation and re-epithelization ? Promotes new blood vessel growth and collagen synthesis
• Facilitates autolytic debridement
• Significantly reduces itching, pain and requires less analgesia
• Highly effective than ‘traditional’ dressings
• Allows undisturbed wound healing with less frequent dressing changes

CLINICAL PHARMACOLOGY
Carboxymethylcellulose
- Allows high absorption of fluids
- Locks exudates and bacteria in the matrix

Polyurethane film on top for high MVTR
- Allows water to evaporate and fresh exudates to be absorbed giving selective permeability

Pectin gelatin for better absorption
- Sticks to the healthy skin only so that there is no adhesion to the moist wound

MECHANISM OF ACTION
After Hydrocoll is applied, wound secretions are absorbed by the hydrocolloids. Constituents of the dressing swell up and change into a gel, which expands into the wound, keeping it moist. The gel remains absorbent until the hydrocolloids are saturated. Saturation of the hydrocolloids is apparent from blistering of the dressing. When absorption occurs, the microcirculation in the wound area is improved at the same time so that body's own cleansing mechanisms are activated especially in the case of chronic wounds where the cleansing phase is stagnating. Hydrocoll absorbs the exudation from the wound and it swells up to form a blister. This condition creates a pressure on the wound that controls the level of exudation from the wound. In the granulation phase, the moist wound environment under Hydrocoll stimulates the activity of the fibroblasts in particular, which play a crucial role in initiating tissue production. Division and migration of the epithelial cells are supported in the epithelialization phase. Hydrocoll maintains the moist wound environment thus preventing the granulation tissue from drying out without the risk of exudates accumulating in the wound even during prolonged application. During epithelialization phase, division and migration of epithelial cells are supported by moist environment. If no complications occur then Hydrocoll can be left on the wound for a few days during this phase until epithelialization is complete. The bacteria and waterproof covering layer acts as a reliable barrier against microorganisms and protects the wound against soiling and moisture. Even the patient can take a shower with the dressing.

INDICATIONS
• Bed sores
• Superficial abrasions
• Ulcers mainly decubitus/venous/arterial

CONTRAINDICATIONS
No listed contraindications

APPLICATION PROCEDURE
• Remove one half of the backing paper
• Place exposed side of Hydrocoll on the wound. Remove second half of the backing paper and apply Hydrocoll fully.
• After applying Hydrocoll, hold the dressing in place with your palm for one minute to ensure optimum adherence.
• Relieve pressure on the wound (in case of pressure sore).

Frequency of change The frequency depends on the level of exudation and the stage of healing. It can be left on the wound for 3-5 days. (The blister formation is an indicator for the dressing change)

PRESENTATION
Hydrocoll 10 x 10 cm,15 x 15 cm Hydrocoll Thin 10 x 10 cm

DESCRIPTION
Molicare Dry Plus is an all in one-incontinence brief with dry plus fluid distribution layer and super absorbent core with wetness indicator.

FEATURES AND BENEFITS
Shape of absorbent pad provides reliable leakage protection as well as protects skin against rewetting. Its shape allows greater freedom of movement. Inner cuffs - This wetness repellent anti-leak cuff provides added protection against leakage at the sides. Fluid distribution layer which is made up of dry plus fibre, guides wetness rapidly in to the new absorbent core, safely away from skin, keeping it comfortably dry. Elastic outer foil provides the perfect fit, fitting the body contours perfectly. Soft elastic threads offers flexible leg gathers with perfect fit and additional leakage protection without pinching. Wetness indicator - The elastic foil backing has a built in wetness indicator. When the word “Molicare” dissolves then it indicates that its time to change Molicare which is very convenient for the patient to understand. Frontal tape makes it possible to re-open and close the adhesive tape several times without difficulty Absorbent core absorbs and reliably holds 10 times its weight in fluid and keeps the wetness away from skin.

INDICATIONS
Specially designed for patients with severe urinary incontinence, highly dependent patients (due to surgery, geriatric population).

Bed protection sheet

DESCRIPTION
Molinea Plus are underpads with an absorbent core of cellulose fluff.

FEATURES & BENEFIT
• Waterproof, non-slip foil backing sealed edge to edge.
• Absorbent core of cellulose fluff with high absorbency.
• Fluid - dispersing tissue layer, which helps to stay dry.
• Non-woven top layer covering the entire surface. All the above advantages make the patient feel comfortable and hygienic.

INDICATIONS
• As an additional bedding protection
• Can also be used in conjunction with other body worn products
• Can also be used during surgical procedures in the operation theatre Excellent as baby's bedding protection

Non-woven dressing retention

DESCRIPTION
Omnifix E is a self adhesive, non-woven fabric for complete cover dressing retention

FEATURES & BENEFITS
• Omnifix E is extremely soft as well as permeable to air and water vapour thus it is well tolerated to the skin even after prolonged application.
• A hypoallergenic adhesive enhances the non-irritant properties of Omnifix E. This adhesive is well tolerated even by the patients with sensitive skin.
• Omnifix E has an excellent adhesive strength yet it can be removed painlessly without leaving residues.
• The non-woven support that is elastic in width enables Omnifix E to be securely and smoothly applied to joints and angular parts of body too.
• Omnifix E does not absorb X-rays (radiolucent) thus can be left in place for radiography.
• Omnifix E is very easy to use; a wave shaped punch cut helps while removing the covering paper.

INDICATIONS
• Complete dressing retention on any part of the body
• For securing probes and catheters

APPLICATION PROCEDURE
Cut the required size Fold over the narrow side of the release paper backing, pull off and stick on Omnifix-E is only stretchable crosswise but not lengthwise. Take this into account while applying Now push over the dressing. Do not pull

PRESENTATION
Omnifix E 5 cm x 10 m rolls Omnifix E 10 cm x 10 m rolls

OXOFERIN

COMPOSITION
Each 30 ml of Oxoferin contains:
Tetrachlorodecaoxide in an aqueous base - q.s.

HIGHLIGHTS (USPs)
• A unique concept in wound healing, which is based on the activation of
macrophage system
• A moist therapy which contains the bioactivated oxygen carrier TCDO i.e.
Tetrachlorodecaoxide anion complex
• Thus an aqueous solution to be used locally to promote wound healing

CLINICAL PHARMACOLOGY
OXOFERIN is an aqueous solution containing Tetrachlorodecaoxide, a nonmetallic
bio-catalytically activated oxygen carrier. It is an effective wound healing
agent.
Upon application, Tetrachlorodecaoxide penetrates the tissue where it stimulates
phagocytosis, leading to a rapid wound cleansing and effective local defense
against infections.
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Activated by bio-catalysis, it is broken down into the physiological metabolitesoxygen
& chloride. This results in an increase of the partial oxygen pressure in
the wound. Formation of bright red granulation tissue with an extremely good
blood supply is accelerated, leading to a significant faster epithelialisation and
formation of smooth scars.
Oxoferin containing TCDO is used for local application to promote wound
healing. The following pharmacological effects are significant for the therapeutic
use of oxoferin in the topical treatment of wounds.
a.) Increasing O2 tension in hypoxic situations.
b.) Increasing phagocytic activity.
c.) Antimicrobial activity.
Increasing O2 tension in hypoxic situations
In vitro & vivo experiments demonstrate the oxygen donor effect of TCDO. In
vitro experiments show that TCDO in the presence of haem proteins leads to
oxygen release. This released oxygen, leads to an elevation of O2 pressure in
the hypoxic tissue regions.
Increasing phagocytic activity
Oxoferin intensifies the phagocYte response and therewith activates the wound
macrophages which can only take on their key function in all three at ages of
wound healing when they are activated:
• Wound cleansing and resistance to infection
• Wound granulation with capillary multiplication and collagen synthesis
• Epithelial closure
Antimicrobial activity
The bactericidal action of TCDO has been demonstrated in vitro. The incubation
of different organisms with TCDO and various proteins in suspension tests
provide an intensification of the TCDO bactericidal action.
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The antimicrobial effect of TCDO appears not to be based on modifications of the
external membrane of the bacterial cell.

INDICATIONS AND USAGE
To promote wound healing in the following wounds :
• Infected wounds
• Delayed post-traumatic wound healing
• Delayed wound healing after amputation
• Decubitus (sacrum, buttocks, heels)
• Tissue preparation for skin graft
• Chronic leg ulcers combined with venous failure
• Delayed wound healing after third degree burns.